Drug interactions
Glucagon intranasal + Insulin glargine
Severity: Minor
Glucagon intranasal and Insulin glargine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and directly opposes the glucose-lowering action of insulin. This is the intended use in severe hypoglycemia, but the rise may be followed by later glucose swings and temporary loss of glycemic control.
What this interaction means in plain words
Glucagon intranasal and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucagon stimulates hepatic glycogenolysis and gluconeogenesis, which is pharmacodynamically opposite to insulin.
What to do
Use glucagon for hypoglycemia as indicated, then monitor glucose after recovery and give carbohydrate. Review the insulin dose to prevent recurrence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Glucagon intranasal with Insulin glargine?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and directly opposes the glucose-lowering action of insulin. This is the intended use in severe hypoglycemia, but the rise may be followed by later glucose swings and temporary loss of glycemic control.
How serious is the interaction between Glucagon intranasal and Insulin glargine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use glucagon for hypoglycemia as indicated, then monitor glucose after recovery and give carbohydrate. Review the insulin dose to prevent recurrence.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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