Drug interactions
Glucagon intranasal + Ipratropium
Severity: Moderate
Glucagon intranasal and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon reduces gastrointestinal motility, and anticholinergics such as ipratropium do likewise. Together they may increase gastrointestinal adverse effects such as constipation or ileus, though inhaled ipratropium has low systemic exposure.
What this interaction means in plain words
Glucagon intranasal and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of gastrointestinal motility via anticholinergic and glucagon effects.
What to do
Glucagon is typically given as a single emergency dose, so no routine change is needed. Monitor for gastrointestinal symptoms if used repeatedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Glucagon intranasal with Ipratropium?
MediHelp rates the interaction as moderate. Glucagon intranasal and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon reduces gastrointestinal motility, and anticholinergics such as ipratropium do likewise. Together they may increase gastrointestinal adverse effects such as constipation or ileus, though inhaled ipratropium has low systemic exposure.
How serious is the interaction between Glucagon intranasal and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Glucagon is typically given as a single emergency dose, so no routine change is needed. Monitor for gastrointestinal symptoms if used repeatedly.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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