Drug interactions
Glyburide + Hydrochlorothiazide-valsartan
Severity: Minor
Glyburide and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The suggested rise in valsartan exposure through transporter inhibition by glyburide is theoretical and of doubtful clinical relevance. The more practical issue is that angiotensin receptor blockers may slightly enhance glucose lowering while the thiazide component may worsen glycemic control.
What this interaction means in plain words
Glyburide and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Possible in vitro OATP1B1 inhibition by glyburide raising valsartan exposure; not an established clinically important effect.
What to do
No dose adjustment is usually needed. Monitor blood glucose and blood pressure when therapy is started or changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Glyburide and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The suggested rise in valsartan exposure through transporter inhibition by glyburide is theoretical and of doubtful clinical relevance. The more practical issue is that angiotensin receptor blockers may slightly enhance glucose lowering while the thiazide component may worsen glycemic control.
How serious is the interaction between Glyburide and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor blood glucose and blood pressure when therapy is started or changed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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