Drug interactions
Glyburide + Ibuprofen
Severity: Moderate
Glyburide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may increase glyburide exposure and enhance its glucose-lowering effect, with a risk of hypoglycemia. Glyburide carries a particularly high hypoglycemia risk, so even small increases matter, especially in older or renally impaired patients.
What this interaction means in plain words
Glyburide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Competition for CYP2C9 metabolism and protein-binding displacement may raise free glyburide concentrations.
What to do
Monitor blood glucose closely during co-use, especially at initiation and discontinuation of ibuprofen, and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Ibuprofen?
MediHelp rates the interaction as moderate. Glyburide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may increase glyburide exposure and enhance its glucose-lowering effect, with a risk of hypoglycemia. Glyburide carries a particularly high hypoglycemia risk, so even small increases matter, especially in older or renally impaired patients.
How serious is the interaction between Glyburide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-use, especially at initiation and discontinuation of ibuprofen, and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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