Drug interactions
Glyburide + Insulin degludec
Severity: Moderate
Glyburide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide with insulin has additive glucose-lowering effects and a notable risk of hypoglycemia, which can be prolonged and severe in older patients or those with renal impairment.
What this interaction means in plain words
Glyburide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Additive effect: sulfonylurea-stimulated endogenous insulin release plus exogenous insulin.
What to do
Monitor blood glucose closely, and reduce the glyburide or insulin dose if hypoglycemia occurs. Consider a sulfonylurea with lower hypoglycemia risk in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin degludec?
MediHelp rates the interaction as moderate. Glyburide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide with insulin has additive glucose-lowering effects and a notable risk of hypoglycemia, which can be prolonged and severe in older patients or those with renal impairment.
How serious is the interaction between Glyburide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, and reduce the glyburide or insulin dose if hypoglycemia occurs. Consider a sulfonylurea with lower hypoglycemia risk in high-risk patients.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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