Drug interactions
Glyburide + Insulin glargine-lixisenatide
Severity: Moderate
Glyburide and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a sulfonylurea to insulin glargine with lixisenatide increases the risk of hypoglycemia, which may be severe. The risk is highest when starting the combination or when renal function or food intake changes.
What this interaction means in plain words
Glyburide and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects: glyburide stimulates insulin secretion, and insulin and lixisenatide add to this.
What to do
Consider lowering the glyburide dose when starting the combination and monitor blood glucose closely. Educate the patient on recognising and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Glyburide and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a sulfonylurea to insulin glargine with lixisenatide increases the risk of hypoglycemia, which may be severe. The risk is highest when starting the combination or when renal function or food intake changes.
How serious is the interaction between Glyburide and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when starting the combination and monitor blood glucose closely. Educate the patient on recognising and treating hypoglycemia.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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