Drug interactions
Glyburide + Insulin glulisine
Severity: Moderate
Glyburide and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide combined with insulin increases the risk of hypoglycemia, which can be prolonged because of glyburide's long-acting active metabolites. Risk is higher with reduced renal function or erratic food intake.
What this interaction means in plain words
Glyburide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin glulisine belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor glucose closely and lower the glyburide or insulin dose if hypoglycemia occurs. Consider a shorter-acting agent in older patients or those with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin glulisine?
MediHelp rates the interaction as moderate. Glyburide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide combined with insulin increases the risk of hypoglycemia, which can be prolonged because of glyburide's long-acting active metabolites. Risk is higher with reduced renal function or erratic food intake.
How serious is the interaction between Glyburide and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and lower the glyburide or insulin dose if hypoglycemia occurs. Consider a shorter-acting agent in older patients or those with renal impairment.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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