Drug interactions
Glyburide + Insulin isophane protamine human
Severity: Moderate
Glyburide and Insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide plus NPH insulin has additive glucose-lowering effects and increases the risk of hypoglycemia, which can be prolonged in renal impairment because of active metabolites.
What this interaction means in plain words
Glyburide and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor glucose closely and reduce the dose of glyburide or insulin when combining. Consider an alternative with lower hypoglycemia risk in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin isophane protamine human?
MediHelp rates the interaction as moderate. Glyburide and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide plus NPH insulin has additive glucose-lowering effects and increases the risk of hypoglycemia, which can be prolonged in renal impairment because of active metabolites.
How serious is the interaction between Glyburide and Insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the dose of glyburide or insulin when combining. Consider an alternative with lower hypoglycemia risk in older or renally impaired patients.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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