Drug interactions
Glyburide + Ivosidenib
Severity: Moderate
Glyburide and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9 and CYP3A4, which may lower glyburide concentrations. Glucose control may worsen.
What this interaction means in plain words
Glyburide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces hepatic CYP enzymes, increasing glyburide metabolism.
What to do
Monitor blood glucose when ivosidenib is started or stopped. Increase the glyburide dose or use an alternative antidiabetic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Glyburide with Ivosidenib?
MediHelp rates the interaction as moderate. Glyburide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9 and CYP3A4, which may lower glyburide concentrations. Glucose control may worsen.
How serious is the interaction between Glyburide and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ivosidenib is started or stopped. Increase the glyburide dose or use an alternative antidiabetic if control is lost.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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