Drug interactions
Glyburide + Mecasermin
Severity: Moderate
Glyburide and Mecasermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin has insulin-like glucose-lowering effects, and glyburide increases insulin secretion. The combination raises the risk of significant hypoglycemia.
What this interaction means in plain words
Glyburide and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Mecasermin belongs to Endocrine.
Why it happens
Additive hypoglycemic effects from IGF-1 receptor activation and sulfonylurea-induced insulin release.
What to do
Monitor blood glucose and reduce the glyburide dose if hypoglycemia occurs. Give mecasermin with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mecasermin
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Mecasermin?
MediHelp rates the interaction as moderate. Glyburide and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin has insulin-like glucose-lowering effects, and glyburide increases insulin secretion. The combination raises the risk of significant hypoglycemia.
How serious is the interaction between Glyburide and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the glyburide dose if hypoglycemia occurs. Give mecasermin with food.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
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