Drug interactions
Glyburide + Prednisolone
Severity: Moderate
Glyburide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone induces hyperglycemia that opposes the effect of glyburide. Diabetic control may deteriorate during steroid therapy and hypoglycemia can occur when the steroid is reduced.
What this interaction means in plain words
Glyburide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism by glucocorticoid-induced insulin resistance and gluconeogenesis.
What to do
Monitor glucose frequently and adjust glyburide dosing or add insulin as required. Reassess doses during steroid taper.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Prednisolone?
MediHelp rates the interaction as moderate. Glyburide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone induces hyperglycemia that opposes the effect of glyburide. Diabetic control may deteriorate during steroid therapy and hypoglycemia can occur when the steroid is reduced.
How serious is the interaction between Glyburide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and adjust glyburide dosing or add insulin as required. Reassess doses during steroid taper.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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