Drug interactions
Glyburide + Sacubitril-valsartan
Severity: Minor
Glyburide and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may inhibit OATP1B1 and so could modestly raise valsartan exposure. In addition, angiotensin receptor blockers can slightly improve insulin sensitivity, so hypoglycemia is conceivable. Clinically important effects are uncommon.
What this interaction means in plain words
Glyburide and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Possible OATP1B1 inhibition reducing hepatic uptake of valsartan, plus a minor pharmacodynamic enhancement of glucose lowering.
What to do
No empiric dose change is needed; monitor blood pressure and blood glucose when starting or stopping either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Glyburide and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may inhibit OATP1B1 and so could modestly raise valsartan exposure. In addition, angiotensin receptor blockers can slightly improve insulin sensitivity, so hypoglycemia is conceivable. Clinically important effects are uncommon.
How serious is the interaction between Glyburide and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor blood pressure and blood glucose when starting or stopping either drug.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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