Drug interactions
Glyburide + Somatrogon
Severity: Moderate
Glyburide and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon is a growth hormone analogue that reduces insulin sensitivity and can raise blood glucose. In patients taking glyburide, glycemic control may deteriorate. Patients with diabetes or impaired glucose tolerance are at greater risk.
What this interaction means in plain words
Glyburide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance opposes the glucose-lowering action of glyburide.
What to do
Monitor blood glucose after starting somatrogon or changing its dose. Adjust the glyburide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Glyburide with Somatrogon?
MediHelp rates the interaction as moderate. Glyburide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon is a growth hormone analogue that reduces insulin sensitivity and can raise blood glucose. In patients taking glyburide, glycemic control may deteriorate. Patients with diabetes or impaired glucose tolerance are at greater risk.
How serious is the interaction between Glyburide and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting somatrogon or changing its dose. Adjust the glyburide dose as needed.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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