Drug interactions
Glyburide-metformin + Indomethacin
Severity: Moderate
Glyburide-metformin and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may enhance the glucose-lowering effect of glyburide, and NSAID-related renal impairment may increase metformin accumulation. Hypoglycemia is the main concern.
What this interaction means in plain words
Glyburide-metformin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement and CYP2C9 competition, plus NSAID-related reduction in renal function.
What to do
Monitor blood glucose when indomethacin is started or stopped and adjust the glyburide dose as needed. Monitor renal function with sustained use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Glyburide-metformin with Indomethacin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin may enhance the glucose-lowering effect of glyburide, and NSAID-related renal impairment may increase metformin accumulation. Hypoglycemia is the main concern.
How serious is the interaction between Glyburide-metformin and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when indomethacin is started or stopped and adjust the glyburide dose as needed. Monitor renal function with sustained use.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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