Drug interactions
Glyburide-metformin + Ketoprofen
Severity: Moderate
Glyburide-metformin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may enhance the glucose-lowering effect of glyburide, occasionally leading to hypoglycemia. NSAID-related renal impairment may also increase metformin accumulation.
What this interaction means in plain words
Glyburide-metformin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement and NSAID-induced reduction in renal function.
What to do
Monitor blood glucose when ketoprofen is started or stopped and reduce the glyburide dose if needed. Check renal function with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Glyburide-metformin with Ketoprofen?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen may enhance the glucose-lowering effect of glyburide, occasionally leading to hypoglycemia. NSAID-related renal impairment may also increase metformin accumulation.
How serious is the interaction between Glyburide-metformin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ketoprofen is started or stopped and reduce the glyburide dose if needed. Check renal function with prolonged use.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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