Drug interactions
Glyburide-metformin + Leniolisib
Severity: Moderate
Glyburide-metformin and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, all of which handle glyburide. Glyburide exposure may therefore increase, raising the risk of hypoglycemia.
What this interaction means in plain words
Glyburide-metformin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits BCRP and OATP1B1/1B3 transporters, reducing glyburide efflux and hepatic uptake.
What to do
Monitor blood glucose closely when starting leniolisib. Lower the glyburide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Leniolisib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Leniolisib
Frequently asked questions
Can I take Glyburide-metformin with Leniolisib?
MediHelp rates the interaction as moderate. Glyburide-metformin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, all of which handle glyburide. Glyburide exposure may therefore increase, raising the risk of hypoglycemia.
How serious is the interaction between Glyburide-metformin and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting leniolisib. Lower the glyburide dose if hypoglycemia develops.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
