Drug interactions
Glyburide-metformin + Levothyroxine
Severity: Moderate
Glyburide-metformin and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases hepatic glucose output and metabolic rate, which can raise blood glucose in diabetic patients. Dose changes or withdrawal of levothyroxine can therefore shift glycemic control.
What this interaction means in plain words
Glyburide-metformin and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Levothyroxine belongs to Endocrine.
Why it happens
Thyroid hormone increases gluconeogenesis, glycogenolysis and intestinal glucose absorption, opposing antidiabetic effects.
What to do
Monitor blood glucose after starting or changing levothyroxine dose. Adjust antidiabetic doses as needed and keep thyroid replacement at a stable euthyroid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Levothyroxine
Frequently asked questions
Can I take Glyburide-metformin with Levothyroxine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases hepatic glucose output and metabolic rate, which can raise blood glucose in diabetic patients. Dose changes or withdrawal of levothyroxine can therefore shift glycemic control.
How serious is the interaction between Glyburide-metformin and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing levothyroxine dose. Adjust antidiabetic doses as needed and keep thyroid replacement at a stable euthyroid dose.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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