Drug interactions
Glyburide-metformin + Maprotiline
Severity: Minor
Glyburide-metformin and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, may alter glycemic control and occasionally potentiate hypoglycemia in patients taking sulfonylureas. The evidence is limited and the effect is usually small.
What this interaction means in plain words
Glyburide-metformin and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Possible additive effects on glucose metabolism and insulin secretion; the mechanism is not clearly established.
What to do
Monitor blood glucose when starting or stopping maprotiline. Counsel the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Maprotiline?
MediHelp rates the interaction as minor. Glyburide-metformin and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline, a tetracyclic antidepressant, may alter glycemic control and occasionally potentiate hypoglycemia in patients taking sulfonylureas. The evidence is limited and the effect is usually small.
How serious is the interaction between Glyburide-metformin and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping maprotiline. Counsel the patient about hypoglycemia symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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