Drug interactions
Glyburide-metformin + Nadolol
Severity: Moderate
Glyburide-metformin and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers can prolong or worsen hypoglycemia and blunt its warning symptoms such as tremor and palpitations. They may also modestly raise blood glucose.
What this interaction means in plain words
Glyburide-metformin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade impairs glycogenolytic recovery from hypoglycemia and masks adrenergic warning signs.
What to do
Monitor blood glucose more often and teach patients that sweating may be the main warning sign. Consider a cardioselective beta-blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Glyburide-metformin with Nadolol?
MediHelp rates the interaction as moderate. Glyburide-metformin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers can prolong or worsen hypoglycemia and blunt its warning symptoms such as tremor and palpitations. They may also modestly raise blood glucose.
How serious is the interaction between Glyburide-metformin and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and teach patients that sweating may be the main warning sign. Consider a cardioselective beta-blocker if one is needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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