Drug interactions
Glyburide-metformin + Nicardipine
Severity: Minor
Glyburide-metformin and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP2C9 in vitro, which could theoretically raise glyburide levels. Calcium channel blockers may also slightly impair glucose tolerance, and clinical significance is uncertain.
What this interaction means in plain words
Glyburide-metformin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP2C9-mediated glyburide metabolism.
What to do
Monitor blood glucose when nicardipine is started or stopped. Reduce the glyburide dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Nicardipine
Frequently asked questions
Can I take Glyburide-metformin with Nicardipine?
MediHelp rates the interaction as minor. Glyburide-metformin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits CYP2C9 in vitro, which could theoretically raise glyburide levels. Calcium channel blockers may also slightly impair glucose tolerance, and clinical significance is uncertain.
How serious is the interaction between Glyburide-metformin and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nicardipine is started or stopped. Reduce the glyburide dose only if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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