Drug interactions
Glyburide-metformin + Nizatidine
Severity: Minor
Glyburide-metformin and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine may modestly increase metformin concentrations by competing for renal tubular secretion. Clinically significant effects are uncommon but the combination could increase metformin exposure in patients with impaired renal function.
What this interaction means in plain words
Glyburide-metformin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Competition for renal tubular secretion via organic cation transporters reduces metformin clearance.
What to do
No routine dose change is needed; monitor glycemic control and renal function, particularly in older patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Glyburide-metformin with Nizatidine?
MediHelp rates the interaction as minor. Glyburide-metformin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nizatidine may modestly increase metformin concentrations by competing for renal tubular secretion. Clinically significant effects are uncommon but the combination could increase metformin exposure in patients with impaired renal function.
How serious is the interaction between Glyburide-metformin and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glycemic control and renal function, particularly in older patients or those with renal impairment.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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