Drug interactions
Glyburide-metformin + Oxaprozin
Severity: Moderate
Glyburide-metformin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the hypoglycemic effect of sulfonylureas such as glyburide. Hypoglycemia is possible, particularly in elderly patients or those with renal impairment.
What this interaction means in plain words
Glyburide-metformin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement and/or reduced clearance of glyburide; the mechanism is not well established.
What to do
Monitor blood glucose when starting oxaprozin and counsel the patient on hypoglycemia symptoms; reduce glyburide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Glyburide-metformin with Oxaprozin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the hypoglycemic effect of sulfonylureas such as glyburide. Hypoglycemia is possible, particularly in elderly patients or those with renal impairment.
How serious is the interaction between Glyburide-metformin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting oxaprozin and counsel the patient on hypoglycemia symptoms; reduce glyburide dose if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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