Drug interactions
Glyburide-metformin + Prednisone
Severity: Moderate
Glyburide-metformin and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisone raises blood glucose and can weaken the effect of glyburide and metformin. Hyperglycemia may be significant with higher doses or longer courses, and glucose may drop when the steroid is withdrawn.
What this interaction means in plain words
Glyburide-metformin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Glucocorticoids increase gluconeogenesis and insulin resistance, opposing the antidiabetic drugs.
What to do
Monitor blood glucose more often during steroid therapy and increase antidiabetic doses if needed. Reduce doses as the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Glyburide-metformin with Prednisone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisone raises blood glucose and can weaken the effect of glyburide and metformin. Hyperglycemia may be significant with higher doses or longer courses, and glucose may drop when the steroid is withdrawn.
How serious is the interaction between Glyburide-metformin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during steroid therapy and increase antidiabetic doses if needed. Reduce doses as the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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