Drug interactions
Glyburide-metformin + Probenecid
Severity: Moderate
Glyburide-metformin and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may reduce the renal elimination of sulfonylureas and can raise glyburide levels, increasing hypoglycemia risk. It may also reduce renal tubular secretion of metformin.
What this interaction means in plain words
Glyburide-metformin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular organic anion and cation transport, reducing clearance of glyburide and metformin.
What to do
Monitor blood glucose and renal function when probenecid is started and reduce the antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Glyburide-metformin with Probenecid?
MediHelp rates the interaction as moderate. Glyburide-metformin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid may reduce the renal elimination of sulfonylureas and can raise glyburide levels, increasing hypoglycemia risk. It may also reduce renal tubular secretion of metformin.
How serious is the interaction between Glyburide-metformin and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when probenecid is started and reduce the antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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