Drug interactions
Glyburide-metformin + Quetiapine
Severity: Moderate
Glyburide-metformin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may counteract the glucose-lowering effect of glyburide and metformin. Glycemic control may deteriorate after quetiapine is started or the dose is raised.
What this interaction means in plain words
Glyburide-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Atypical antipsychotic-related metabolic effects produce insulin resistance and hyperglycemia, opposing antidiabetic drugs pharmacodynamically.
What to do
Check fasting glucose and HbA1c at baseline and periodically after starting quetiapine. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Glyburide-metformin with Quetiapine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may counteract the glucose-lowering effect of glyburide and metformin. Glycemic control may deteriorate after quetiapine is started or the dose is raised.
How serious is the interaction between Glyburide-metformin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and periodically after starting quetiapine. Adjust antidiabetic therapy as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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