Drug interactions
Glyburide-metformin + Quinidine
Severity: Moderate
Glyburide-metformin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may raise metformin exposure by competing for renal tubular secretion. Higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in patients with reduced renal function.
What this interaction means in plain words
Glyburide-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine, a cationic drug, competes with metformin for renal tubular transporters (OCT2/MATE) and reduces its renal clearance.
What to do
Monitor glucose and renal function, and watch for signs of metformin toxicity. Reduce the metformin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Quinidine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may raise metformin exposure by competing for renal tubular secretion. Higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in patients with reduced renal function.
How serious is the interaction between Glyburide-metformin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function, and watch for signs of metformin toxicity. Reduce the metformin dose if adverse effects occur.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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