Drug interactions
Glyburide-metformin + Regorafenib
Severity: Moderate
Glyburide-metformin and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit the efflux transporter BCRP, which could increase systemic exposure to glyburide. This may enhance glucose lowering and the risk of hypoglycemia, although clinical data are limited.
What this interaction means in plain words
Glyburide-metformin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Regorafenib belongs to Oncology.
Why it happens
Inhibition of BCRP (ABCG2) by regorafenib may reduce efflux of glyburide and raise its plasma levels.
What to do
Monitor blood glucose closely after starting regorafenib and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Regorafenib
Frequently asked questions
Can I take Glyburide-metformin with Regorafenib?
MediHelp rates the interaction as moderate. Glyburide-metformin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit the efflux transporter BCRP, which could increase systemic exposure to glyburide. This may enhance glucose lowering and the risk of hypoglycemia, although clinical data are limited.
How serious is the interaction between Glyburide-metformin and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting regorafenib and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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