Drug interactions
Glyburide-metformin + Rifapentine
Severity: Moderate
Glyburide-metformin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic drug-metabolizing enzymes, which can lower glyburide exposure and weaken glycemic control. Rifapentine may also reduce metformin exposure to some extent. Blood glucose may rise during rifapentine therapy and fall again after it is stopped.
What this interaction means in plain words
Glyburide-metformin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP2C9 and other enzymes, increasing glyburide clearance.
What to do
Monitor blood glucose closely when rifapentine is started and increase the antidiabetic dose if needed. Reassess and reduce the dose after rifapentine is stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Rifapentine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces hepatic drug-metabolizing enzymes, which can lower glyburide exposure and weaken glycemic control. Rifapentine may also reduce metformin exposure to some extent. Blood glucose may rise during rifapentine therapy and fall again after it is stopped.
How serious is the interaction between Glyburide-metformin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when rifapentine is started and increase the antidiabetic dose if needed. Reassess and reduce the dose after rifapentine is stopped to avoid hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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