Drug interactions
Glyburide-metformin + Ritonavir
Severity: Moderate
Glyburide-metformin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can alter glyburide concentrations, and protease inhibitors are associated with insulin resistance and hyperglycemia. The net effect is unpredictable and can be loss of glucose control or occasionally hypoglycemia.
What this interaction means in plain words
Glyburide-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir modulates CYP enzymes and transporters affecting glyburide, and protease inhibitors can impair insulin sensitivity.
What to do
Monitor blood glucose frequently after starting or stopping ritonavir and adjust antidiabetic doses accordingly. Consider an alternative agent if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Ritonavir?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can alter glyburide concentrations, and protease inhibitors are associated with insulin resistance and hyperglycemia. The net effect is unpredictable and can be loss of glucose control or occasionally hypoglycemia.
How serious is the interaction between Glyburide-metformin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently after starting or stopping ritonavir and adjust antidiabetic doses accordingly. Consider an alternative agent if control is poor.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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