Drug interactions
Glyburide-metformin + Secobarbital
Severity: Moderate
Glyburide-metformin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower glyburide concentrations and reduce glycemic control. Loss of effect may be gradual and may reverse when the barbiturate is stopped.
What this interaction means in plain words
Glyburide-metformin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce hepatic enzymes, including CYP2C9, increasing glyburide metabolism.
What to do
Monitor blood glucose when starting or stopping secobarbital and adjust the antidiabetic dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Secobarbital?
MediHelp rates the interaction as moderate. Glyburide-metformin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower glyburide concentrations and reduce glycemic control. Loss of effect may be gradual and may reverse when the barbiturate is stopped.
How serious is the interaction between Glyburide-metformin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping secobarbital and adjust the antidiabetic dose accordingly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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