Drug interactions
Glyburide-metformin + Semaglutide
Severity: Moderate
Glyburide-metformin and Semaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide combined with a sulfonylurea increases the risk of hypoglycemia. Reduced appetite and delayed gastric emptying from semaglutide can contribute further.
What this interaction means in plain words
Glyburide-metformin and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Additive glucose-dependent insulin stimulation from semaglutide and glucose-independent insulin release from glyburide.
What to do
Consider reducing the glyburide dose when starting semaglutide and monitor blood glucose. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Semaglutide
Frequently asked questions
Can I take Glyburide-metformin with Semaglutide?
MediHelp rates the interaction as moderate. Glyburide-metformin and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide combined with a sulfonylurea increases the risk of hypoglycemia. Reduced appetite and delayed gastric emptying from semaglutide can contribute further.
How serious is the interaction between Glyburide-metformin and Semaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting semaglutide and monitor blood glucose. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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