Drug interactions
Glyburide-metformin + Sulindac
Severity: Moderate
Glyburide-metformin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs including sulindac can occasionally potentiate sulfonylurea-induced hypoglycemia. NSAIDs may also impair renal function, which raises the risk of metformin accumulation.
What this interaction means in plain words
Glyburide-metformin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
NSAIDs may displace sulfonylureas from protein binding or alter prostaglandin-mediated insulin effects, and renal effects may reduce metformin clearance.
What to do
Monitor blood glucose and renal function during concurrent use. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Glyburide-metformin with Sulindac?
MediHelp rates the interaction as moderate. Glyburide-metformin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs including sulindac can occasionally potentiate sulfonylurea-induced hypoglycemia. NSAIDs may also impair renal function, which raises the risk of metformin accumulation.
How serious is the interaction between Glyburide-metformin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during concurrent use. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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