Drug interactions
Glyburide-metformin + Tranylcypromine
Severity: Moderate
Glyburide-metformin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can lower blood glucose and enhance hypoglycemia from sulfonylureas such as glyburide. Cases of severe hypoglycemia have been reported with the MAOI class.
What this interaction means in plain words
Glyburide-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin secretion and glucose-lowering effects; the exact mechanism is not fully established.
What to do
Monitor blood glucose closely when starting, stopping or adjusting tranylcypromine and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Tranylcypromine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can lower blood glucose and enhance hypoglycemia from sulfonylureas such as glyburide. Cases of severe hypoglycemia have been reported with the MAOI class.
How serious is the interaction between Glyburide-metformin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, stopping or adjusting tranylcypromine and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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