Drug interactions
Glyburide-metformin + Verapamil
Severity: Moderate
Glyburide-metformin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may inhibit hepatic uptake of metformin through organic cation transporters, which can reduce its glucose-lowering effect. Verapamil has also been associated with altered glucose control in some patients.
What this interaction means in plain words
Glyburide-metformin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of OCT1-mediated hepatic uptake of metformin by verapamil.
What to do
Monitor blood glucose after starting or stopping verapamil and titrate the metformin dose if control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Glyburide-metformin with Verapamil?
MediHelp rates the interaction as moderate. Glyburide-metformin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may inhibit hepatic uptake of metformin through organic cation transporters, which can reduce its glucose-lowering effect. Verapamil has also been associated with altered glucose control in some patients.
How serious is the interaction between Glyburide-metformin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping verapamil and titrate the metformin dose if control changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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