Drug interactions
Glyburide-metformin + Voclosporin
Severity: Moderate
Glyburide-metformin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin inhibits OATP1B1, and glyburide is an OATP1B1 substrate, so exposure to glyburide may increase. This could heighten the risk of hypoglycemia, particularly in patients with renal impairment such as those with lupus nephritis.
What this interaction means in plain words
Glyburide-metformin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of glyburide by voclosporin.
What to do
Monitor blood glucose after starting voclosporin and reduce the glyburide dose if hypoglycemia occurs. Also monitor renal function because of metformin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Voclosporin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin inhibits OATP1B1, and glyburide is an OATP1B1 substrate, so exposure to glyburide may increase. This could heighten the risk of hypoglycemia, particularly in patients with renal impairment such as those with lupus nephritis.
How serious is the interaction between Glyburide-metformin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting voclosporin and reduce the glyburide dose if hypoglycemia occurs. Also monitor renal function because of metformin.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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