Drug interactions
Glyburide-metformin + Warfarin
Severity: Moderate
Glyburide-metformin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonylureas and warfarin are both CYP2C9 substrates and are highly protein bound, so each may modestly alter the other's effect. INR changes and hypoglycemia have been reported, although the interaction is inconsistent.
What this interaction means in plain words
Glyburide-metformin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Competition for CYP2C9 metabolism and plasma protein binding between glyburide and warfarin.
What to do
Check INR more frequently when starting or stopping glyburide-metformin and monitor blood glucose for hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Glyburide-metformin with Warfarin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonylureas and warfarin are both CYP2C9 substrates and are highly protein bound, so each may modestly alter the other's effect. INR changes and hypoglycemia have been reported, although the interaction is inconsistent.
How serious is the interaction between Glyburide-metformin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more frequently when starting or stopping glyburide-metformin and monitor blood glucose for hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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