Drug interactions
Glycerol phenylbutyrate + Prednisone
Severity: Moderate
Glycerol phenylbutyrate and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids promote protein catabolism and can raise ammonia, counteracting the ammonia-lowering aim of glycerol phenylbutyrate in urea cycle disorders. This can precipitate hyperammonemia.
What this interaction means in plain words
Glycerol phenylbutyrate and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Prednisone belongs to Endocrine.
Why it happens
Corticosteroid-induced protein breakdown increases nitrogen load and plasma ammonia.
What to do
Monitor plasma ammonia closely when starting, stopping or changing prednisone doses. Adjust glycerol phenylbutyrate dose and dietary protein as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Glycerol phenylbutyrate with Prednisone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and can raise ammonia, counteracting the ammonia-lowering aim of glycerol phenylbutyrate in urea cycle disorders. This can precipitate hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting, stopping or changing prednisone doses. Adjust glycerol phenylbutyrate dose and dietary protein as needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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