Drug interactions
Glycopyrrolate + Scopolamine
Severity: Moderate
Glycopyrrolate and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antimuscarinics, so combined use increases dry mouth, constipation, urinary retention, tachycardia, blurred vision and heat intolerance. Scopolamine also crosses into the CNS, so confusion may occur, particularly in older patients.
What this interaction means in plain words
Glycopyrrolate and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Scopolamine belongs to Respiratory.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid duplicate anticholinergic therapy when possible. If both are needed, monitor for urinary retention, ileus, tachycardia and cognitive effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Scopolamine?
MediHelp rates the interaction as moderate. Glycopyrrolate and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antimuscarinics, so combined use increases dry mouth, constipation, urinary retention, tachycardia, blurred vision and heat intolerance. Scopolamine also crosses into the CNS, so confusion may occur, particularly in older patients.
How serious is the interaction between Glycopyrrolate and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate anticholinergic therapy when possible. If both are needed, monitor for urinary retention, ileus, tachycardia and cognitive effects.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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