Drug interactions
Glycopyrrolate + Tolterodine
Severity: Moderate
Glycopyrrolate and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combined use adds to anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Elderly patients are at higher risk of confusion.
What this interaction means in plain words
Glycopyrrolate and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid duplicating anticholinergic therapy where possible; monitor for urinary retention, constipation and cognitive effects and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Tolterodine?
MediHelp rates the interaction as moderate. Glycopyrrolate and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combined use adds to anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Elderly patients are at higher risk of confusion.
How serious is the interaction between Glycopyrrolate and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating anticholinergic therapy where possible; monitor for urinary retention, constipation and cognitive effects and reduce doses if they occur.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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