Drug interactions
Glycopyrrolate inhaled + Ipratropium
Severity: Moderate
Glycopyrrolate inhaled and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled antimuscarinic bronchodilators, so together they duplicate therapy and add to anticholinergic effects such as dry mouth, urinary retention and glaucoma worsening. They offer no clear added benefit over one agent.
What this interaction means in plain words
Glycopyrrolate inhaled and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid using two short- or long-acting antimuscarinics together; choose one agent. If both are given, monitor for urinary retention and ocular effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Glycopyrrolate inhaled with Ipratropium?
MediHelp rates the interaction as moderate. Glycopyrrolate inhaled and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled antimuscarinic bronchodilators, so together they duplicate therapy and add to anticholinergic effects such as dry mouth, urinary retention and glaucoma worsening. They offer no clear added benefit over one agent.
How serious is the interaction between Glycopyrrolate inhaled and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two short- or long-acting antimuscarinics together; choose one agent. If both are given, monitor for urinary retention and ocular effects.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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