Drug interactions
Glycopyrrolate inhaled + Perphenazine
Severity: Minor
Glycopyrrolate inhaled and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic properties that can add to those of glycopyrrolate, causing dry mouth, constipation, urinary retention, blurred vision and tachycardia. Inhaled glycopyrrolate has low systemic exposure, so the effect is usually modest but may matter in older or vulnerable patients.
What this interaction means in plain words
Glycopyrrolate inhaled and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and confusion, particularly in older adults. Reduce or stop one agent if symptoms become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Glycopyrrolate inhaled with Perphenazine?
MediHelp rates the interaction as minor. Glycopyrrolate inhaled and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has anticholinergic properties that can add to those of glycopyrrolate, causing dry mouth, constipation, urinary retention, blurred vision and tachycardia. Inhaled glycopyrrolate has low systemic exposure, so the effect is usually modest but may matter in older or vulnerable patients.
How serious is the interaction between Glycopyrrolate inhaled and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and confusion, particularly in older adults. Reduce or stop one agent if symptoms become troublesome.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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