Drug interactions
Glycopyrronium + Henbane
Severity: Moderate
Glycopyrronium and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with glycopyrronium it can cause additive anticholinergic effects such as dry mouth, tachycardia, urinary retention and confusion.
What this interaction means in plain words
Glycopyrronium and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid concurrent use of henbane with glycopyrronium. If unavoidable, monitor for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Henbane?
MediHelp rates the interaction as moderate. Glycopyrronium and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with glycopyrronium it can cause additive anticholinergic effects such as dry mouth, tachycardia, urinary retention and confusion.
How serious is the interaction between Glycopyrronium and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of henbane with glycopyrronium. If unavoidable, monitor for anticholinergic toxicity.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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