Drug interactions
Glycopyrronium + Meclizine
Severity: Moderate
Glycopyrronium and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antihistamine with anticholinergic activity, so combination with glycopyrronium increases dry mouth, blurred vision, constipation, urinary retention and drowsiness or confusion.
What this interaction means in plain words
Glycopyrronium and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Meclizine belongs to Respiratory.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Monitor for anticholinergic effects and cognition, especially in older adults, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Meclizine
Frequently asked questions
Can I take Glycopyrronium with Meclizine?
MediHelp rates the interaction as moderate. Glycopyrronium and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an antihistamine with anticholinergic activity, so combination with glycopyrronium increases dry mouth, blurred vision, constipation, urinary retention and drowsiness or confusion.
How serious is the interaction between Glycopyrronium and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and cognition, especially in older adults, and use the lowest effective doses.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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