Drug interactions
Glycopyrronium + Metoclopramide intranasal
Severity: Moderate
Glycopyrronium and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium slows gastrointestinal motility and opposes the prokinetic action of metoclopramide. This may blunt the therapeutic effect of metoclopramide in gastroparesis.
What this interaction means in plain words
Glycopyrronium and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: muscarinic blockade opposes metoclopramide's cholinergic prokinetic action.
What to do
Monitor gastroparesis symptom control and avoid the combination if possible. Consider reducing or stopping the anticholinergic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Glycopyrronium and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium slows gastrointestinal motility and opposes the prokinetic action of metoclopramide. This may blunt the therapeutic effect of metoclopramide in gastroparesis.
How serious is the interaction between Glycopyrronium and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor gastroparesis symptom control and avoid the combination if possible. Consider reducing or stopping the anticholinergic.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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