Drug interactions
Glycopyrronium + Olanzapine / samidorphan
Severity: Moderate
Glycopyrronium and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity that adds to glycopyrronium and may cause severe constipation, ileus and urinary retention. Tachycardia and confusion may also occur.
What this interaction means in plain words
Glycopyrronium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects reducing gastrointestinal and urinary tract motility.
What to do
Monitor bowel function and urinary symptoms and treat constipation early. Reduce or stop the anticholinergic if hypomotility develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Glycopyrronium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity that adds to glycopyrronium and may cause severe constipation, ileus and urinary retention. Tachycardia and confusion may also occur.
How serious is the interaction between Glycopyrronium and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms and treat constipation early. Reduce or stop the anticholinergic if hypomotility develops.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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