Drug interactions
Glycopyrronium + Olanzapine
Severity: Moderate
Glycopyrronium and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has moderate anticholinergic activity, so combining it with glycopyrronium may intensify dry mouth, constipation, urinary retention and tachycardia. Severe constipation and ileus are the main concerns.
What this interaction means in plain words
Glycopyrronium and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Olanzapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel function, urinary symptoms and heart rate, and use a bowel regimen if needed. Reduce or stop one agent if anticholinergic toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Olanzapine
Frequently asked questions
Can I take Glycopyrronium with Olanzapine?
MediHelp rates the interaction as moderate. Glycopyrronium and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has moderate anticholinergic activity, so combining it with glycopyrronium may intensify dry mouth, constipation, urinary retention and tachycardia. Severe constipation and ileus are the main concerns.
How serious is the interaction between Glycopyrronium and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary symptoms and heart rate, and use a bowel regimen if needed. Reduce or stop one agent if anticholinergic toxicity develops.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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