Drug interactions
Glycopyrronium + Pimozide
Severity: Moderate
Glycopyrronium and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide has some anticholinergic activity that may add to glycopyrronium effects, causing dry mouth, constipation and urinary retention. Pimozide also prolongs the QT interval, though glycopyrronium does not clearly add to that risk.
What this interaction means in plain words
Glycopyrronium and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Pimozide?
MediHelp rates the interaction as moderate. Glycopyrronium and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide has some anticholinergic activity that may add to glycopyrronium effects, causing dry mouth, constipation and urinary retention. Pimozide also prolongs the QT interval, though glycopyrronium does not clearly add to that risk.
How serious is the interaction between Glycopyrronium and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce doses if they occur.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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