Drug interactions
Glycopyrronium + Trihexyphenidyl
Severity: Moderate
Glycopyrronium and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trihexyphenidyl is a potent central and peripheral anticholinergic, and adding glycopyrronium increases the risk of dry mouth, constipation, urinary retention, tachycardia, heat intolerance and confusion. Paralytic ileus is a rare but serious outcome.
What this interaction means in plain words
Glycopyrronium and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Monitor for anticholinergic toxicity including bowel function and mental status, and reduce doses if needed. Take extra care in older patients and in hot environments.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Glycopyrronium with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Glycopyrronium and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trihexyphenidyl is a potent central and peripheral anticholinergic, and adding glycopyrronium increases the risk of dry mouth, constipation, urinary retention, tachycardia, heat intolerance and confusion. Paralytic ileus is a rare but serious outcome.
How serious is the interaction between Glycopyrronium and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity including bowel function and mental status, and reduce doses if needed. Take extra care in older patients and in hot environments.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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