Drug interactions
Glycopyrronium + Trospium chloride
Severity: Moderate
Glycopyrronium and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are quaternary antimuscarinics, so together they add up anticholinergic effects. Patients may experience dry mouth, constipation, urinary retention, blurred vision and tachycardia.
What this interaction means in plain words
Glycopyrronium and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blockade of muscarinic receptors (pharmacodynamic synergism).
What to do
Avoid combining two antimuscarinics when possible. If used together, monitor for urinary retention, constipation and tachycardia, and reduce one dose if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Trospium chloride?
MediHelp rates the interaction as moderate. Glycopyrronium and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are quaternary antimuscarinics, so together they add up anticholinergic effects. Patients may experience dry mouth, constipation, urinary retention, blurred vision and tachycardia.
How serious is the interaction between Glycopyrronium and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antimuscarinics when possible. If used together, monitor for urinary retention, constipation and tachycardia, and reduce one dose if effects emerge.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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