Drug interactions
Glycopyrronium + Trospium
Severity: Moderate
Glycopyrronium and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so together they increase the risk of dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are particularly vulnerable to confusion and ileus.
What this interaction means in plain words
Glycopyrronium and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Trospium belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid duplicate antimuscarinic therapy when possible; if both are needed, monitor for anticholinergic toxicity and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Trospium?
MediHelp rates the interaction as moderate. Glycopyrronium and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so together they increase the risk of dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are particularly vulnerable to confusion and ileus.
How serious is the interaction between Glycopyrronium and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy when possible; if both are needed, monitor for anticholinergic toxicity and use the lowest effective doses.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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